Selected “Hot Topic” Talks

Latest data on the “Big Data” analysis implicating HHV-6A & HHV-6 in Alzheimer’s
-Joel Dudley, Director, Institute for Next Generation Healthcare

HHV-6A impact in a 3D cell culture model of Alzheimer’s
-Robert Moir, Harvard University and MGH Institute for Neurodegenerative Disease

HHV-6A infection of microglial cells induces the expression of Alzheimer’s disease risk factors.
Roberta Rizzo, Department of Medical Sciences University of Ferrara, Italy

Herpesviruses & the Impact on Autophagy in Alzheimer’s
-Xiaonan Dong, Center for Autophagy Research, UT Southwestern Medical Center 

Herpesviruses & pathology of the olfactory tract
-Lavinia Alberi Auber, Lead of Neurology Research, Swiss Integrative Center for Human Health, Switzerland

Additional talks to be announced soon.

Human herpesvirus 6 alters mitochondrial function and can synergize with underlying disease state to promote disease progression in human T cells
Christine Birdwell, Texas A & M Health Science Center, Texas, USA

Latency associated U94A disrupts neuronal and glial cell function
Margot Mayer-Proschel, University of Rochester, NY, USA

HHV-6 U24 in multiple sclerosis: mechanism triggering autoimmunity?
Suzana Straus, University of British Columbia, Department of Chemistry, Vancouver, Canada

Serological response against HHV-6A is associated with increased risk for multiple sclerosis
Rasmus Gustafsson, Karolinska Institute, Stockholm, Sweden

β-herpesviruses in brain autopsies at University Teaching Hospital, Lusaka, Zambia
-John Tembo, University Teaching Hospital, Zambia

HHV-6A induces proinflammatory MS associated retrovirus via receptor engagement
-Branka Horvat, INSERM, France

 HHV-6A infection of CD4 transgenic mice
-Cynthia Leifer, Cornell, NY, USA

Using murine roseolovirus to study HHV-6/7 reactivation
-Xiaofeng Zhou, University of Michigan, Lung Immunobiology Lab, USA

Modeling Alzheimer’s disease: from rodents to non-human primates
Takaomi Saido, PhD, RIKEN Center for Brain Science, Japan

ciHHV6 reactivation in peripheral blood lymphocytes
-Mary Alice Allnut & Steve Jacobson, NINDS/NIH, USA

Tissue specific inherited ciHHV-6 RNA expression in vivo
-Vikas Peddu, Fred Hutch Cancer Research Center, University of Washington

Phylogenetics and natural history of inherited ciHHV-6
-Amr Aswad, Institute for Virology, Free University & Pascale Bonnafous, INSERM

Excision of inherited ciHHV-6 using CRISPR/Cas9 technology
-Guilia Aimola, Institute for Virology, Freie Universistät

Impact of herpesvirus load and genome diversity on infant development
-Ursula Gompels, London School of Hygiene & Tropical Medicine, London, UK

Recurrent endogenization of HHV-6 on chromosome 22q in Japan
-Nick Parrish, Riken Center for Integrative Medical Sciences, Japan

When herpesviruses meet telomeres: toward a better understanding of HHV-6A/B chromosomal integration
-Vanessa Collin,  CHU de Quebec research center-Laval University, Canada

Phylogeny of inherited chromosomally integrated (ici) and community HHV-6A and -6B strains
-Pascale Bonnafous, Sorbonne Université, INSERM, France

Mapping the transcriptome
-Annie Gravel, CHU de Québec Research Center, University Laval

Transformation of T and B cells by coinfection of HHV-6 and EBV
-Janos Luka, Bioworld Consulting Laboratories

HHV-6 MicroRNAs in serum and spinal fluid of MS patients
-Maria Dominguez-Mozo, Hospital Clinico San Carlos

HHV-6A small non-coding RNA U14 alters miR-30 processing via direct interaction
-Bhupesh Prusty, University of Würzburg

Humanization of murine neutralizing antibodies against HHV-6B
-Lidya Tjan, Center for Infectious Diseases, Kobe University Graduate School of Medicine

U94 induces apoptosis by blocking DNA repair mechanisms
-Francesca Caccuri, Department of Molecular and Translational Medicine, University of Brescia

Molecular interaction of HHV-6B gH/gL/gQ1/gQ2 complex with the cellular receptor and neutralizing antibodies
-Mitsuhiro Nishimura, Center for Infectious Diseases, Kobe University School of Medicine, Japan

Vaccine Development for HHV-6B
Yasuko Mori, Center for Infectious Diseases, Kobe University Graduate School of Medicine

 HHV-6A infection of endometrial cells induces a defective trophoblast invasion
-Daria Bortolotti, Microbiology and Medical Genetics, University of Ferrara

Donor-derived memory CD4 T cells and HHV-6 reactivation after HCT
-Derek Hanson, Vaccine & Infectious Disease Division, University of Washington

HHV-6 in the lymphoma microenvironment
-Genevieve Crane, Weill Cornell Medical College

Does HHV-6 promote malignancy? An overview
-Eva Eliassen, HHV-6 Foundation

HHV-6 and HLA-B*13:01 both confer increased risk of environmental hypersensitivity
-Dafeng Lin, Shenzen Prevention and Treatment Center for Occupational Diseases, China

HLA interaction with HHV-6: heterologous immunity model
-David Ostrov, Department of Pathology, University of Florida

HHV-6 and thymic reconstitution after UCBT
-Vassiliki Boussiotis, MD, PhD, Beth Israel Deaconess Medical Center, Harvard Medical School

Human Herpesvirus 6B and Lower Respiratory Tract Disease after Allogeneic Hematopoietic Cell Transplantation
-Josh Hill, MD Fred Hutchinson Cancer Research Center, University of Washington, Seattle USA

The biological plausibility of human herpesvirus 6 reactivation after allo-HCT inducing idiopathic pneumonia syndrome and aggravating acute GVHD
-Bethany Moore, PhD,  Lung Immunobiology Lab, University of Michigan

Impact of HHV6 in recipients of T-cell depleted HCT
-Genovefa A. Papanicolaou, MD, Memorial Sloan-Kettering Cancer Center, New York, USA

Predicting HHV-6B reactivation by ratio of CD134/CD4 T cell ratio before conditioning
– Takehiko Mori, MD, PHD, Division of Hematology,Keio University School of Medicine

Impact of IL-6 and other cytokines on HHV-6 reactivation
– Hiroya Tamaki, MD, PhD, Department of Internal Medicine, Hyogo College of Medicine